The aim of this study was to develop and psychometrically validate the Iranian scale of patient privacy and confidentiality. This methodological study was conducted in two stages: first, a conventional content analysis was used to qualitatively identify concepts of privacy and confidentiality. Then, the face validity, content validity, and construct validity were assessed. Internal consistency coefficient and total consistency were checked. KMO and Bartlett’s test were used to examine thequestionnaire for factor analysis. EFA identified seven factors that accounted for 55.25% of the total variance in the questionnaire score. The total Cronbach’s α coefficient was 0.84 for the whole instrument. The Spearman reliability coefficient of the instrument was 0.91 using the test–retest method.The final Iranian version of the Patient Privacy and Confidentiality Scale can be used as a valid and reliable instrument to measure the rate of observation of patient privacy and confidentiality.