Marthanda Varma Sankaran Valiathan was born in Mavelikara in the district of Alappuzha, of Travancore State (now Kerala). In an interview, he credited his parents for his interest in Sanskrit, Malayalam, English, music and ethical conduct. There were several physicians in his family. One of his uncles, Dr VS Valiathan, had studied in Edinburgh in 1902. He decided to follow in his uncle’s footsteps
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