Vol , Issue Date of Publication: August 19, 2025
DOI: https://doi.org/10.20529/IJME.2025.065

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Reconsidering the ethics of off-label medication use: A response to Braillon and Naudet on baclofen use in alcohol use disorders in India

Dheeraj Kattula
Abstract:

High diffusion of the use of baclofen in patients with alcohol use disorders (AUD) in India has raised concerns from Braillon and Naudet. They say the practice is based on poor evidence and ignores possible harms to patients. This article critiques their arguments and makes a reasoned, ethical, and evidence-informed case for baclofen as a treatment option for AUD, albeit a second-line one, especially because of issues with acceptability and cost of other approved pharmacotherapies.


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©Indian Journal of Medical Ethics 2025: Open Access and Distributed under the Creative Commons license ( CC BY-NC-ND 4.0),
which permits only non-commercial and non-modified sharing in any medium, provided the original author(s) and source are credited.

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