Donald W Light, Antonio F Maturo. Good pharma: the public-health model of the Mario Negri Institute New York: Palgrave Macmillan, 2015. 288 pp. Hardback $ 95, ISBN 9781137388339. The world of innovation remains divorced from the world of clinical practice and the two intersect only when clinical practice, primed by the pharmaceutical industry's publicity machinery, uncritically laps up all that "big pharma" has to offer. Seldom is clinical research guided by clinical practice and its requirements. New medicines target illusory surrogate end points that might have little to add in terms of actual therapeutic value.