Human papillomavirus vaccines, complex regional pain syndrome, postural orthostatic tachycardia syndrome, and autonomic dysfunction – a review of the regulatory evidence from the European Medicines Agency

Tom Jefferson, Lars Jørgensen

Abstract

Recent concerns about a possible association between exposure of young women to human papillomavirus (HPV) vaccines and two “dysautonomic syndromes” (a collection of signs and symptoms thought to be caused by autoimmunity) — complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) — led the European Medicines Agency (EMA) to review existing evidence. The review was announced by the EMA on July 13, 2015, and was completed on November 4, 2015.

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